Federal officials said a Bronx man, Narcisco Negrum, 45, and a second man, Jose Castillo, 44, from Manhattan, have been charged with various offenses following what they said was a long-term investigation into fentanyl/heroin packaging and distribution in New York City. A third man, Jose Lopez Paulino, 42, of Bridgeport, CT, had also been charged with related offenses by The Office of the Special Narcotics Prosecutor (SNP).